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During the Clone Wars, Ti supervised the training of clone cadets on Kamino, working alongside mercenary instructors and Kaminoan scientists. She served as a mentor to cadets such as Echo and Fives and defended Kamino against a Separatist assault.
Late in the war, Ti had to deal with a mystery: a tumor found in the brain of a clone trooper named Tup. Ti found herself in a power struggle with the Kaminoans, and wrestling with disturbing questions about the clones’ origin and ultimate purpose.